On this page you can find relevant researchs on drug-related health topics, including HIV, hepatitis C, drug and overdose prevention, harm reduction and drug treatment. You can also find our Clinical Guidelines.

Doctor's street-level views could change the course of the opioid crisis
A staggering 64,000 people in the United States died in 2016 from drug overdoses, marking a 22 percent rise from the previous year of a cause of death that now annually exceeds those caused by motor vehicle accidents and gun violence.
From failed global drug prohibition to regulating the drug market
The failure of global drug prohibition, now increasingly acknowledged, demands urgent consideration of an alternative approach which is politically feasible while also respecting powerful market forces. Regulating as much of the drug market as possible is the only realistic option notwithstanding the political and other difficulties of achievement.
Exposure-Response Association Between Concurrent Opioid and Benzodiazepine Use and Risk of Opioid-Related Overdose in Medicare Part D Beneficiaries
How does the risk of overdose change with the number of days with concurrent opioid and benzodiazepine use?
The misuse of benzodiazepines among high-risk opioid users in Europe
This paper describes the impact of benzodiazepines misuse on the health and treatment of high-risk opioid users.
Drug consumption rooms: an overview of provision and evidence
Supervised drug consumption facilities, where illicit drugs can be used under the supervision of trained staff, have been operating in Europe for the last three decades. These facilities primarily aim to reduce the acute risks of disease transmission through unhygienic injecting, prevent drug-related overdose deaths and connect high-risk drug users with addiction treatment and other health and social services.
Primary care-based buprenorphine taper vs maintenance therapy for prescription opioid dependence: a randomized clinical trial.

Among patients dependent on prescription opioids, ongoing maintenance therapy using a legal opiate substitute (buprenorphine–naloxone) produced better outcomes than tapered withdrawal, with patients less likely to have used illicit opioids and considerably more likely to have remained in their allocated treatment.
The National Drug- Related Deaths Database (Scotland) Report Analysis of Deaths occurring in 2015 and 2016
The National Drug-Related Deaths Database (NDRDD) was established to collect detailed information regarding the nature and circumstances of people who had a Drug-Related Death (DRD) in Scotland. This is the seventh report and covers the calendar years 2015 and 2016 with trend data from 2009.
Effect of restricting the legal supply of prescription opioids on buying through online illicit marketplaces: interrupted time series analysis
To examine the effect on the trade in opioids through online illicit markets (“cryptomarkets”) of the US Drug Enforcement Administration’s ruling in 2014 to reschedule hydrocodone combination products.
Overdose Day
Penington Institute has a vision of a world where nobody dies from an accidental drug overdose and where people can talk openly about their experience without stigma.
Naloxone is an easy-to-use, lifesaving antidote to overdose from heroin or other opioids. Used in hospitals for decades, the medication has no abuse potential, costs as little as one dollar for a lifesaving dose and can be administered with basic training.
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